2. シグナル伝達
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog 関連製品 (2419):

製品番号 製品名 製品効果 純度 構造式
  • HY-125818C
    Cytidine-5'-triphosphate disodium hydrate
    Cytidine 5′-triphosphate is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate disodium hydrate
  • HY-W108399
    3’-O-t-Bulyldimethylsilylthymidine 99.04%
    3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-t-Bulyldimethylsilylthymidine
  • HY-I0100
    Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside
    Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside
  • HY-155743A
    ddUTP lithium, 100 mM in H2O 99.16%
    ddUTP (lithium), 100 mM in H2O is a nucleotide analog that can be incorporated into DNA, RNA, or other nucleic acids. ddUTP (lithium), 100 mM in H2O can be used to prepare DNA/RNA hybridization experiments, such as Southern blots and Northern blots.
    ddUTP lithium, 100 mM in H2O
  • HY-111531
    DMTr-LNA-5MeU-3-CED-phosphoramidite 98.75%
    DMTr-LNA-5MeU-3-CED-phosphoramidite is a Phosphoramidite derivative and Nucleoside derivative.
    DMTr-LNA-5MeU-3-CED-phosphoramidite
  • HY-154262
    N6-Ethyl-2’-deoxyadenosine 98.84%
    N6-Ethyl-2’-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N6-Ethyl-2’-deoxyadenosine
  • HY-138130
    L-Guanosine 98.0%
    L-Guanosine is the L-configuration of Guanosine (HY-N0097). L-Guanosine is a purine nucleoside with anti-herpesvirus activity. L-Guanosine can be used to prepare supramolecular hydrogel.
    L-Guanosine
  • HY-154374
    5’-Azido-2’,5’-dideoxyuridine 98.22%
    5’-Azido-2’,5’-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-Azido-2’,5’-dideoxyuridine
  • HY-152358
    N3-Methyl-2’-O-methyluridine
    N3-Methyl-2’-O-methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    N3-Methyl-2’-O-methyluridine
  • HY-152330
    2’-Chloro-N6-(3-methoxy)benzyl adenosine 99.83%
    2’-Chloro-N6-(3-methoxy)benzyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Chloro-N6-(3-methoxy)benzyl adenosine
  • HY-152318
    Adenosine-2-carboxamide 98.23%
    Adenosine-2-carboxamide is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Adenosine-2-carboxamide
  • HY-138601
    5'-O-DMT-N4-Bz-5-Me-dC
    5'-O-DMT-N4-Bz-5-Me-dC is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
    5'-O-DMT-N4-Bz-5-Me-dC
  • HY-152732
    6-Methyluridine 99.02%
    6-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    6-Methyluridine
  • HY-131481
    Mnm5s2U
    Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA.
    Mnm5s2U
  • HY-132815
    Fostroxacitabine bralpamide
    Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide proagent. Fostroxacitabine bralpamide has anticancer effects.
    Fostroxacitabine bralpamide
  • HY-138582
    N6-Methyl-dA phosphoramidite 99.83%
    N6-Methyl-dA phosphoramidite can be used in the synthesis of oligodeoxyribonucleotides.
    N6-Methyl-dA phosphoramidite
  • HY-111641
    3'-Azido-3'-deoxy-5-fluorocytidine 99.90%
    3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) is a cytidine derivative. 3'-Azido-3'-deoxy-5-fluorocytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3'-Azido-3'-deoxy-5-fluorocytidine
  • HY-W394432
    9-(2-Deoxy-beta-D-ribofuranosyl)-6-methylpurine
    (2R,3S,5R)-2-(hydroxymethyl)-5-(6-methyl-9H-purin-9-yl)tetrahydrofuran-3-ol (9-(2-Deoxy-beta-D-ribofuranosyl)-6-methylpurine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    9-(2-Deoxy-beta-D-ribofuranosyl)-6-methylpurine
  • HY-125818S6
    Cytidine-5'-triphosphate-15N3 dilithium
    Cytidine-5'-triphosphate-15N3 (Cytidine triphosphate-15N3 dilithium; 5'-CTP-15N3) dilithium is 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate-<sup>15</sup>N<sub>3</sub> dilithium
  • HY-152752
    2’,3’-Dideoxy-3’-fluorocytidine
    2’,3’-Dideoxy-3’-fluorocytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’,3’-Dideoxy-3’-fluorocytidine